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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18455b6cc40766eab8c42b1d56deaac08f9cf4391a9f3d2ffe5e9de2068ef018' 
  AND token = 'EhNvoxVR5dh5qna9zGfT1v+Rhxj0MrryLGTmnLqOhKY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}