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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'defb27f895de1b88a88e36c704cfabf4778f4749f1c4866a85c5dd4b8f74c7a7' 
  AND token = 'p84x2QGpTroQ4qreCpk0L7f9PVgchh00sQJhFeUd3kw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}