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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ef87d0d57f7909b1c53df2f9de1f8cc1c1359413ddb3edabca505bed20cfd6f' 
  AND token = 'Ja0VNY7X8fVWwSWaTiS8pVW8rx3WsWwreALUUxX5BOg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}