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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b45322ed2525a63981a2b9f30ed8573d22f8aa34ad0569d71726bd7ba5d4ea91' 
  AND token = 'IlNiZ0TzltwViL/H0PW4BEAtx4N4RtdjAkrNFN5kO9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}