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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7ec6c6532a4dcefc14481d7a3080b6fda49376f7efb62a0a1186af05d5d21e5a' 
  AND token = 'qIiE7NZCG+6M9q7hSaXKGnseW9VqDN5uHJnjEZpXCNs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}