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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72f9b7ceebbdab917d27e1978f79d8e865183447a14478e1b7e49d180a43b307' 
  AND token = 'swP9dWRZ55gGO4gwm2uAYnGPG37hmEWULvGoZhaZ434=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}