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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eaf21f37012ec75a14789e275d2973e813d78ca9f54a90d00e560cdd6a1d850b' 
  AND token = 'Ze4buvJ4AUWH12uPyVoxUw7F6z3aSPoMUe4YXx6gucg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}