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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6281d9d43acde4f6dfa037ce417c61fcac319cccc6f3b030cd63f087d14b3a26' 
  AND token = 'ECmWVIMGYdjPMVfe4w5d+n1lA7Yj1Qf7jxXc/rYf6ZE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}