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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4375e6d88a14fc32c3d24c55e2953426666817c1b2f67b3e0463b2b50a1830cf' 
  AND token = 't+Eysjf5WmzOAe8cC3JWB2w1WJxMi3dBKr+7CNWGuVI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}