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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e42157286b79254be5d2b6b33a9ad890682a4b44e802d7a53b271f7436a3d199' 
  AND token = 'VbKGnRXxZS+X5x6zqtMV3ealWLyL/AEyW42uTpQLmaM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}