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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5a78b34630761ecc431e2b04cbd44a81caf34f275d6f4234ba5afa63c9c2f1b' 
  AND token = 'KU+v7Q0TZ91ANTstCZl30XtxtgidVVdRxrw0sIF2gjs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}