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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0be303c520558a88080aa7cd7f52f1216afa7aafccdb7d7d08d72144bea8352f' 
  AND token = 'Uf5iw+DB2EGoOR3gvyZtFTiCdSyxWB7fAD4Ow0pah9g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}