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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78288d0f2518dc2e958e2cf41e0dde14d11741f9e9be054710f6ff3da27e909c' 
  AND token = '51K3yZ4PlKlYGL9BB/ap7Y3IME2x8dd6lHbb5NC1ia8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}