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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd21d9651fe373d3c4e22a26b80d6de1724d18a01f06d730359eb0a0bdcb71da8' 
  AND token = 'sVXNH2DsnqoM6p2LVGUSXWmKMZS478zdTW5tVASqW/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}