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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e06c21a1c796b0b5648f75f8ec7ded853a60b75ff3cb4d16e7dade37db37f73' 
  AND token = 'uq9I4OmqUO8ZSNz0isd5oJlepCmd0KyAiHDCFH/9/uE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}