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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21162fe4973b8a66dadddc43cb289dc3d848fc27dcaa67b0d5cd20b90a79b49f' 
  AND token = '0Tlq4ojWAD2w7JjnEFjU+4wKHXkOjwoQJ2F7vCmEndc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}