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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4281814ffdb62e4a07ba62fee97c6e92e8bead121f1a99a85958599466a39838' 
  AND token = 'pgu2kFL+VTVk2v29H/7d1BK/4cGVxXPu/t2kP99PVqI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}