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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ec2f22ff244bb1343916e74c7a243cd88f6767dddad57538b92cc96e79e8950' 
  AND token = 'AmDox42mugQ3n1Ufw2AeRLoTpJ7SdBXATIUGtGzW1bM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}