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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49078bae0f08abd2f67eef41f176954021034909fc44a794c03b8e41cea8be94' 
  AND token = '7T3SJtrMus5Fm+CY2Tzw59fTw02xRgKLbGIaReBJ8tU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}