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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef709dec41e81ec3fe88c8e22e538f7997f071ba6a5af941da651651b8d1d165' 
  AND token = '/sx1LR/w4CRYOeh9J3nsUwL9wo0ME1YD0IZBFW2ICwU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}