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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3303d63f29623cb3e56ec3cd3d3be5bc4563b76ee539f99f1df0e91a06b44d77' 
  AND token = 'qMPyZ3OlLj/qV+i57tBLbIQoW4zxQ7SOjUN+E+dUDd0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}