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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42adaa0a0246f44d32516ff1fe9e570e4a8d3eedfa3a468eac0c8de70778203b' 
  AND token = 'pKaCEGzUBnpA+wY1CvGSHSCrSl7pWsatZ87h5RUc2nM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}