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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd428278bc9f0d67c916fe07a3ff5718b577477457643782d2fc49a14cc14c2a0' 
  AND token = 'v96L4Th+/X5faLyRArSutfL5pfw5GMaZgDXvkDuFA5o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}