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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fc4c21cb50d9ab75340a91aaff24a68e9425bd2eeb63fc7354a009c23234d4e0' 
  AND token = 'qWLS46k1LaHiYWTv8K8GBRtlceZ+A70s+tJ1YR0hXGQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}