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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22350b99e8d5e306d2659817385bd9f7a73bf6ea17e5360b5df04925209be8c6' 
  AND token = 'D50VZCoMR2uhaFago3C+mlopzO5b/QJw3u/NrLOqFNs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}