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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16525261d86ea8ad2cb8a25c8f8d49aaa56d30abb581cf0fd45b61de724292f5' 
  AND token = 'HXYSbviAx2aOJ/mS2joHgKRPLiCB41G0x2rB/EvYVkM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}