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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b490a9c4e9d7838d4cf9ffe1316eed08d005994c40c091d958a018bd6b332b4d' 
  AND token = 'R4CMz1Fv4+JHVGbW0Kqwr/xRbfZVyz3tUulWnEiJEgc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}