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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '648da1fd794d84273b92b876e45f8d9eb38badf7ddf06cdab04da6e6bc081af5' 
  AND token = 'kVaNaAvHNtPeEp6Lvo9p0r0GLMBaqds4lM5CIOdH3uk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}