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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '274da875dd5651c03cb792737b0e170a79c5dd9ab2fd5a93be9df3ff023eef01' 
  AND token = 'XUMRe5Zl6E3VbsQpcP0SLX3siUCHac+YuT1WKHyg9s0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}