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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b0f1616072385d510d81cc728f435049c564a1343ff110e186bc358b7b04229' 
  AND token = 'XqZEk6QkZc5JQoRl6+yB7zVxe15hgS++kxkuMJ8AZgI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}