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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4217d7ce10323d9a1f5dd1b7e528a17d2fdc5a961785b45eefb70169776b4b64' 
  AND token = 'OJCoMwwptb/rYx4oz9Fd5eJIGO7i+tRP3NHjEUAwtk4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}