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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9374cbb00af87f782897a37b7e2013021e4e7c55805cb9620900d5f014b36a20' 
  AND token = 'UskUBZCtqnNEAO8BBD0PbeF1q3BC2WR9hyyQmnP2qBg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}