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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '295f1abb61f3f6e714bb79188f00ebbef6d05be28b5b6f30ad721560cbb1b47b' 
  AND token = 'aucW8Nds3U/1FHyLKM71yLMLj3DXKhRe/AyKv+ynxe8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}