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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '849d22a54a67de95f4eadc0dcd16ddbd60700d9e81d3403a72c0c2de14f5af70' 
  AND token = 'zkpVI5lg0qQ0QesfBgpb4MM3ARL09VYD6zbRZ5fwCZA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}