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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e4f01f04568fc373cbc67dac4764b67ca522209dae1c38f5d5e1652414418ca' 
  AND token = 'YSjn86a/ScpSiMJsHaq2Hnf4D67TwG7PQx8ZiC4zVcA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}