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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '455370caf3a6f7ef3b7e3568525621a604c3394644d0e6e75272fe754e22662a' 
  AND token = '1x9q6N55LWyXABPG0EXrBGdS+Ed1LqUKx57MLjKeyxQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}