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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a1d15eaccc21e1e06372ebfdf1a89bcf11ff2bd5290ff8aaef3c3fa88901287' 
  AND token = '+3hstB2+aIe3TH2VK9T/U6EE0JzZmRzrKn/9WChTn/A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}