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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '394ff0a7c3bce1a634918d72ef9d2c432d7c506822ab6e89401377534b3ee38d' 
  AND token = 'nniooG+bgXKsoPYq6CAbcs53ZW7vQnXN7ZMlToZKpC4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}