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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b57e27a2c6dbbf509973345d7cdc393211e4007504648816a5a8aeb4f58eff40' 
  AND token = 'EahRQ+nY7ckhHyIXxSDCF4KM9uoDC1T6v2sWoKIEa4Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}