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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '242178f3c41fca516662f40c92d36a57f52effb34619f42a5ddd91d8fefe83b3' 
  AND token = 'pr5xP6PR0xCxkcDMUAgyxfiDs7ngmMyrn5p9seK8m0g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}