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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49dffa03b210a36526598dff660cc86072a1c951f6ff0092c9e1b47a8c816200' 
  AND token = 'lcBAT4vycYAD29H0KI28Ee55h5qcvEyMFdBXMvdQsi8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}