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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '652bd29998a993b29f9d395db3f43b8f316025ae62ba73e0b86315822ae1b249' 
  AND token = 'cMFHNLvAOW7pt+XU8Njm7FaJ//cxk8N3zqyxVvCf4mo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}