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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18ace3b703dcb3822409fa698d129f0d2351730b02c10c8b50054aadb4922f13' 
  AND token = '0HrO4iDRITrrlBHvT/1TvGA9lgsNBmFPDuDIamSXEOQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}