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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ca53e3c550031c33281062b0f2402f62520f949d0e2a49ef5a4312967cafe534' 
  AND token = 'YQ/c6S3E4Eq7puBVp07u/rXdGOtlVIjLe65Rm6WynjM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}