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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0610c4dd158e00209b2bd4a5e12be6c068d5f77065614b4e5c8b502a6f82e999' 
  AND token = 'kmiyhMUDD8Aqsdha5xZKSPkSAIeMX4xuzOzg/Ruhbqo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}