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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57b548fde95b9c2d162840d15ad6d9172791823b2453b020f030010bd78b0f36' 
  AND token = 'nS7JUFWtynzvFf5u5eiWLTiaQBR+BzDQPGFIH4mh7eU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}