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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '20187d7c876fec8029a0a87cb4cd0b7a1bbf85e21ca40f445a16424787538935' 
  AND token = '4kV572GBGN22O3hDpGbSKwqrf9CGlZV+G6uaaNXerV8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}