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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f5c900922aa94b757f1f9a00d0bbf00e787fcfc37c20a7d9482ed860ce023221' 
  AND token = 'DQ+0Rq/FPsC1RENZSRKC0AC+oxjIvRHYL7f8h/wuWXY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}