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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '428d1b303152f900a7621d1b746b552a82533511f72c1596d6956a970188170e' 
  AND token = 'PP2uukFGE3rLVW+ppGdiBYR4dfBC31fNtmgqWr60PUg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}