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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4f7f46a1a7a103ca068dc6b9103c05d28c6c4c51a90401989cac50b167208d2' 
  AND token = 'nPEAComI6SLPPJC474Y3+rY+Ijj0Cjw8fyJv1w/dhGA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}